The comprehensive study on the role of POSTN in fetal congenital heart disease and clinical applications
Yi Xia, Liang Chen, JinWen Lu, Jianhong Ma, Yuanzhen Zhang · 2023
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Description
Yi Xia, Liang Chen, JinWen Lu, Jianhong Ma, and Yuanzhen Zhang study a protein called periostin and its role in fetal heart defects. Their 2023 paper notes that congenital heart disease is the most common birth defect. The group's earlier work flagged periostin and a second protein, PAPPA, as possible markers in pregnancy fluids.
They confirmed the markers shift in mothers carrying affected fetuses: periostin falls and PAPPA rises. Mice lacking the periostin gene developed atrial septal defects, holes between the heart's upper chambers. Cell studies traced how the protein guides heart development. A combined marker model was tested for prenatal screening value. The screening model combines both markers in one score.
Catalog record
| CREATOR | Yi Xia, Liang Chen, JinWen Lu, Jianhong Ma, Yuanzhen Zhang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |