Cirsiliol induces autophagy and mitochondrial apoptosis through the AKT/FOXO1 axis and influences methotrexate resistance in osteosarcoma
Mengliang Luo, Zexin Su, Haotian Gao, Jianye Tan, Rongdong Liao, Jiancheng Yang, Lijun Lin · 2023
Read Cirsiliol induces autophagy and mitochondrial apoptosis through the AKT/FOXO1 axis and influences methotrexate resistance in osteosarcoma by Mengliang Luo, Zexin Su, Haotian Gao, Jianye Tan, Rongdong Liao, Jiancheng Yang, Lijun Lin (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10714637.txt.
Description
Mengliang Luo and co-authors test a plant compound against osteosarcoma, a bone cancer of the young, in a study from two thousand twenty-three. The compound, cirsiliol, had shown anti-tumor hints in other cancers. Both drug-sensitive and drug-resistant bone cancer cell lines were treated, and tumors were grown in mice.
The compound slowed cell growth, triggered cell death, and stalled the cell cycle. It damaged mitochondria and raised self-eating activity inside cells. Docking and lab checks showed it targets the AKT protein, freeing a partner factor that harms the tumor. Mouse tumors also shrank. The authors call it a promising treatment lead.
Catalog record
| CREATOR | Mengliang Luo, Zexin Su, Haotian Gao, Jianye Tan, Rongdong Liao, Jiancheng Yang, Lijun Lin |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |