Network pharmacology combined with metabolomics to explore the mechanism for Lonicerae Japonicae flos against respiratory syncytial virus
Jie Ding, Jing Li, Zhe Zhang, Yaxuan Du, Yuhong Liu, Ping Wang, Haitao Du · 2023
Read Network pharmacology combined with metabolomics to explore the mechanism for Lonicerae Japonicae flos against respiratory syncytial virus by Jie Ding, Jing Li, Zhe Zhang, Yaxuan Du, Yuhong Liu, Ping Wang, Haitao Du (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10714634.txt.
Description
Jie Ding and co-authors probe how honeysuckle flower, a traditional Chinese medicine, fights respiratory syncytial virus, in a 2023 study. The virus is a leading cause of lung infection and hospital stays in infants.
The team combined network analysis with chemical profiling. Computers linked twenty-three active compounds in the flower to virus-related targets, naming three core ones. Lab tests on infected cells confirmed a real antiviral effect. Treated cells showed shifts in eighteen small molecules tied to fat and purine pathways. Docking tests showed several compounds bind their targets well. The authors offer the map as a guide for deeper study and clinical use.
Catalog record
| CREATOR | Jie Ding, Jing Li, Zhe Zhang, Yaxuan Du, Yuhong Liu, Ping Wang, Haitao Du |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |