A protocol for a single center, randomized, controlled trial comparing the clinical efficacy of 3% diquafosol and 0.1% hyaluronic acid in diabetic patients with dry eye disease
Jiayan Chen, Yimeng Chen, Guanghao Qin, Liangzhe Li, Mingze Li, Yuan Cheng, Shuting Zhuang, Zhihui Li, Qing Zhang, Yi Wu, Lanting Yang, Salissou Moutari, Jonathan E. Moore, Ling Xu, Wei He, Sile Yu, Emmanuel Eric Pazo, Xingru He · 2023
Read A protocol for a single center, randomized, controlled trial comparing the clinical efficacy of 3% diquafosol and 0.1% hyaluronic acid in diabetic patients with dry eye disease by Jiayan Chen, Yimeng Chen, Guanghao Qin, Liangzhe Li, Mingze Li, Yuan Cheng, Shuting Zhuang, Zhihui Li, Qing Zhang, Yi Wu, Lanting Yang, Salissou Moutari, Jonathan E. Moore, Ling Xu, Wei He, Sile Yu, Emmanuel Eric Pazo, Xingru He (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10714480.txt.
Description
Jiayan Chen, Yimeng Chen, Guanghao Qin, and fifteen colleagues lay out a head-to-head eye drop trial in this two thousand twenty-three protocol paper. Diabetes is rising, and about seventy percent of diabetic people have dry eye disease, which damages the corneal surface and nerves while tear production falls. Anti-inflammatory treatments exist, but two drops, three percent diquafosol and zero point one percent hyaluronic acid, had never been rigorously compared in diabetic dry eye.
The planned single-center, triple-blind randomized trial assigns two hundred two patients equally to either drop, one drop six times daily for eight weeks. Outcomes span the tear film, corneal staining and sensitivity, tear inflammation markers, meibomian gland function, corneal nerves, and symptom questionnaires, measured at baseline and weeks four and eight. The protocol promises a standardized verdict on which drop better serves diabetic patients, whose dry eye is common but understudied.
Catalog record
| CREATOR | Jiayan Chen, Yimeng Chen, Guanghao Qin, Liangzhe Li, Mingze Li, Yuan Cheng, Shuting Zhuang, Zhihui Li, Qing Zhang, Yi Wu, Lanting Yang, Salissou Moutari, Jonathan E. Moore, Ling Xu, Wei He, Sile Yu, Emmanuel Eric Pazo, Xingru He |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |