Unveiling the role of miR-137-3p/miR-296-5p/SERPINA3 signaling in colorectal cancer progression: integrative analysis of gene expression profiles and in vitro studies
Huimin Liu, Xingxing Wu, Dandan Wang, Quanxi Li, Xin Zhang, Liang Xu · 2023
Read Unveiling the role of miR-137-3p/miR-296-5p/SERPINA3 signaling in colorectal cancer progression: integrative analysis of gene expression profiles and in vitro studies by Huimin Liu, Xingxing Wu, Dandan Wang, Quanxi Li, Xin Zhang, Liang Xu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10714458.txt.
Description
Colorectal cancer spreads in ways that are still not fully mapped at the gene level. Huimin Liu and co-authors combined data analysis with lab tests in 2023 to find genes tied to that spread. They merged three public gene datasets, looked for genes whose levels differed in spreading tumors, and singled out a hub gene called SERPINA3 for closer study.
In two cancer cell lines, raising SERPINA3 made cells grow and move more and resist cell death. Two small RNA molecules had the opposite effect, and their effect faded when SERPINA3 was raised again. The team reads this as a signaling chain that helps the cancer progress and could serve as a treatment target.
Catalog record
| CREATOR | Huimin Liu, Xingxing Wu, Dandan Wang, Quanxi Li, Xin Zhang, Liang Xu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |