Phase-separated CCER1 coordinates the histone-to-protamine transition and male fertility
Dongdong Qin, Yayun Gu, Yu Zhang, Shu Wang, Tao Jiang, Yao Wang, Cheng Wang, Chang Chen, Tao Zhang, Weiya Xu, Hanben Wang, Ke Zhang, Liangjun Hu, Lufan Li, Wei Xie, Xin Wu, Zhibin Hu · 2023
Read Phase-separated CCER1 coordinates the histone-to-protamine transition and male fertility by Dongdong Qin, Yayun Gu, Yu Zhang, Shu Wang, Tao Jiang, Yao Wang, Cheng Wang, Chang Chen, Tao Zhang, Weiya Xu, Hanben Wang, Ke Zhang, Liangjun Hu, Lufan Li, Wei Xie, Xin Wu, Zhibin Hu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10713660.txt.
Description
Dongdong Qin and co-authors report a fertility study, published in 2023, on a protein that helps sperm package their DNA. Late in sperm formation, the loose histone proteins holding DNA are swapped for protamines that pack it tightly. The team found a germ cell protein called CCER1 that forms liquid like droplets inside the nucleus and drives that swap.
Mice lacking the protein made sperm with poorly packed DNA and were infertile. The protein raised production of the swap proteins and guided chemical marks on histones during the change. In people, broken versions of the same gene turned up in five men whose testes made no sperm. None appeared in more than two thousand fertile controls. That contrast ties the droplet mechanism to human fertility.
Catalog record
| CREATOR | Dongdong Qin, Yayun Gu, Yu Zhang, Shu Wang, Tao Jiang, Yao Wang, Cheng Wang, Chang Chen, Tao Zhang, Weiya Xu, Hanben Wang, Ke Zhang, Liangjun Hu, Lufan Li, Wei Xie, Xin Wu, Zhibin Hu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |