Deciphering the role of immunoglobulin secreting malignant lineages in the invasive frontiers of small cell lung cancer by scRNA-seq and spatial transcriptomics analysis
Fei Wu, Xiao Zhang, Minglei Wang, Jingxin Zhang, Minxin Chen, Ziyuan Ren, Meng Wu, Pingping Song, Jinming Yu, Dawei Chen · 2023
Read Deciphering the role of immunoglobulin secreting malignant lineages in the invasive frontiers of small cell lung cancer by scRNA-seq and spatial transcriptomics analysis by Fei Wu, Xiao Zhang, Minglei Wang, Jingxin Zhang, Minxin Chen, Ziyuan Ren, Meng Wu, Pingping Song, Jinming Yu, Dawei Chen (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10713609.txt.
Description
Fei Wu and co-authors map odd cell lineages at lung cancer edges in a 2023 letter. Small cell lung cancer spreads early and resists care, and its known subtypes fail to predict outcomes well. Antibody-secreting malignant cells at the invasion front drew the team's focus.
Single-cell gene reads joined maps of where cells sit in tissue. The pairing lets the team see which lineages crowd the front and how they talk to immune neighbors. Subtype labels based on four factors miss this spatial mix. The letter argues the front's odd lineages may drive spread and deserve targeted study.
Catalog record
| CREATOR | Fei Wu, Xiao Zhang, Minglei Wang, Jingxin Zhang, Minxin Chen, Ziyuan Ren, Meng Wu, Pingping Song, Jinming Yu, Dawei Chen |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |