Is Protein BLAST a thing of the past?
Ali Al-Fatlawi, Martin Menzel, Michael Schroeder · 2023
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Description
Ali Al-Fatlawi, Martin Menzel, and Michael Schroeder ask whether structure search will retire the classic protein search tool BLAST in this 2023 opinion piece. BLAST has matched sequences for three decades, but prediction breakthroughs now give nearly every known protein a folded three dimensional model.
The authors weigh the promise for finding distant relatives: sequences can drift far apart while the fold, and so the function, stays alike, as one algae and bacteria adhesion pair shows. Structure search can catch what sequence search misses. Even so, they argue BLAST should not be discarded; the sequence tool should instead learn to fold structural information into its searches.
Catalog record
| CREATOR | Ali Al-Fatlawi, Martin Menzel, Michael Schroeder |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 10 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |