Targeted Imaging of Endometriosis and Image-Guided Resection of Lesions Using Gonadotropin-Releasing Hormone Analogue-Modified Indocyanine Green
Jing Peng, Qiyu Liu, Tao Pu, Mingxing Zhang, Meng Zhang, Ming Du, Guiling Li, Xiaoyan Zhang, Congjian Xu · 2023
Read Targeted Imaging of Endometriosis and Image-Guided Resection of Lesions Using Gonadotropin-Releasing Hormone Analogue-Modified Indocyanine Green by Jing Peng, Qiyu Liu, Tao Pu, Mingxing Zhang, Meng Zhang, Ming Du, Guiling Li, Xiaoyan Zhang, Congjian Xu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10713253.txt.
Description
Peng and co-authors built a glowing probe that homes in on endometriosis so surgeons can find and remove every lesion. Endometriosis tissue carries a hormone receptor that healthy tissue mostly lacks. They attached a hormone-like targeting molecule to a near-infrared dye, making a probe that sticks to the receptor. Tests in cells and in mice compared the targeted probe with the plain dye.
The targeted probe bound far more strongly to endometriosis cells. In mice it lit up the lesions clearly within hours and kept a clean signal for two days, while the plain dye wandered into the gut. Surgery guided by the probe removed lesions with about 97 percent sensitivity, far better than white-light surgery, and safety tests showed no clear harm. The authors present the probe as a practical aid for complete lesion removal.
Catalog record
| CREATOR | Jing Peng, Qiyu Liu, Tao Pu, Mingxing Zhang, Meng Zhang, Ming Du, Guiling Li, Xiaoyan Zhang, Congjian Xu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |