The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis development
Mei-Feng Chen, Chih-Chien Hu, Yung-Heng Hsu, Yu-Chih Lin, Kai-Lin Chen, Steve W N Ueng, Yuhan Chang · 2023
Read The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis development by Mei-Feng Chen, Chih-Chien Hu, Yung-Heng Hsu, Yu-Chih Lin, Kai-Lin Chen, Steve W N Ueng, Yuhan Chang (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10713244.txt.
Description
Mei-Feng Chen and six colleagues investigated a protein called EDIL3 as a possible protector of joint cartilage. Damaged human cartilage contains much more EDIL3 than undamaged cartilage, but its effect was unknown. Agents that prevent cartilage cell loss and matrix breakdown are needed against osteoarthritis. The twenty twenty-three study used human cartilage plugs in the lab and mice that develop osteoarthritis spontaneously.
Giving EDIL3 protein kept cartilage cells evenly distributed and preserved their numbers in the plugs. In mice, it slowed disease progression and maintained matrix-producing cells. Breakdown of aggrecan, a key matrix component, was reduced. Damage scores fell and the bone plate under the cartilage became more porous. The results suggest EDIL3 actively defends cartilage rather than merely marking damage, making it a candidate therapy.
Catalog record
| CREATOR | Mei-Feng Chen, Chih-Chien Hu, Yung-Heng Hsu, Yu-Chih Lin, Kai-Lin Chen, Steve W N Ueng, Yuhan Chang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |