Protective and Adverse Roles of DDX3X in Different Cell Types in Nonalcoholic Steatohepatitis Progression
Suzhen Yang, Lin Zhou, Tianming Zhao, Hanlong Zhu, Tingting Luo, Kang Jiang, Xiaoxiao Shi, Chunyan Chen, Han Zhang, Si Zhao, Xiaoping Zou, Yuzheng Zhuge, Fangyu Wang, Lei Wang, Mingzuo Jiang, Bing Xu · 2023
Read Protective and Adverse Roles of DDX3X in Different Cell Types in Nonalcoholic Steatohepatitis Progression by Suzhen Yang, Lin Zhou, Tianming Zhao, Hanlong Zhu, Tingting Luo, Kang Jiang, Xiaoxiao Shi, Chunyan Chen, Han Zhang, Si Zhao, Xiaoping Zou, Yuzheng Zhuge, Fangyu Wang, Lei Wang, Mingzuo Jiang, Bing Xu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10712874.txt.
Description
Suzhen Yang and a large team of co-authors present a 2023 study of one protein playing hero and villain in fatty liver disease. NASH, the inflamed form of fatty liver, worsens under metabolic stress. The protein DDX3X sits at a fork: it helps build stress granules that protect cells, yet also helps assemble an inflammasome that harms them.
Patient livers showed the protein concentrated in macrophages and liver cells, and reduced in disease. The team bred mice missing the protein in one cell type or the other and fed them liver-straining diets. Macrophage-specific loss improved the liver picture in the reported comparisons. That split result is the paper's point: the same molecule defends one cell type and endangers another. Cell-targeted therapy would have to respect the difference.
Catalog record
| CREATOR | Suzhen Yang, Lin Zhou, Tianming Zhao, Hanlong Zhu, Tingting Luo, Kang Jiang, Xiaoxiao Shi, Chunyan Chen, Han Zhang, Si Zhao, Xiaoping Zou, Yuzheng Zhuge, Fangyu Wang, Lei Wang, Mingzuo Jiang, Bing Xu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |