Downregulation of GDF15 suppresses ferroptosis and predicts unfavorable prognosis in clear cell renal cell carcinoma
Dongliang Yang, Zhongyin He, Jiawei Lu, Xiaolin Yuan, Haiyong Liu, Yagang Xue, Ting Chen, Hongxing Gu · 2023
Read Downregulation of GDF15 suppresses ferroptosis and predicts unfavorable prognosis in clear cell renal cell carcinoma by Dongliang Yang, Zhongyin He, Jiawei Lu, Xiaolin Yuan, Haiyong Liu, Yagang Xue, Ting Chen, Hongxing Gu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10712134.txt.
Description
Dongliang Yang and co-authors study a growth factor's role in kidney cancer in this 2023 paper. The factor, GDF15, runs low in clear cell renal cell carcinoma tissue. The team mined a large cancer dataset, then tested two kidney cancer cell lines in the lab. Lowering GDF15 made the cells grow, spread, and invade more.
Raising it had the opposite effect, slowing growth and invasion. Pathway analysis pointed to ferroptosis, an iron-driven form of cell death. Cells with less GDF15 held less iron and less of the damage marker tied to ferroptosis. The authors conclude that losing GDF15 shields tumors from this death route, matching poorer patient survival.
Catalog record
| CREATOR | Dongliang Yang, Zhongyin He, Jiawei Lu, Xiaolin Yuan, Haiyong Liu, Yagang Xue, Ting Chen, Hongxing Gu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |