The effect of nanoparticle coating on biological, chemical and biophysical parameters influencing radiosensitization in nanoparticle-aided radiation therapy
Elham Mansouri, Asghar Mesbahi, Hamed Hamishehkar, Soheila Montazersaheb, Vahid Hosseini, Saeed Rajabpour · 2023
Read The effect of nanoparticle coating on biological, chemical and biophysical parameters influencing radiosensitization in nanoparticle-aided radiation therapy by Elham Mansouri, Asghar Mesbahi, Hamed Hamishehkar, Soheila Montazersaheb, Vahid Hosseini, Saeed Rajabpour (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10712124.txt.
Description
Elham Mansouri and five co-authors review how nanoparticle coatings change radiosensitization in cancer therapy in this 2023 paper. Metal particles placed in a tumor boost the local dose from radiation. Coatings are added to cut toxicity, stop clumping, and guide particles to tumor cells. Yet the coat itself alters the physics and chemistry of the boost. Under low energy photons, a coat can absorb the low energy electrons that drive local dose gains, shielding the particle.
The coat seems to act more on the chemical stage, where reactive oxygen species form, than on the first physical stage. Irradiated coated particles lowered cancer cell survival more than normal cell survival in the studies reviewed. The authors frame coat design as a trade: delivery gains against dose losses. Coat choice must fit the radiation energy in use.
Catalog record
| CREATOR | Elham Mansouri, Asghar Mesbahi, Hamed Hamishehkar, Soheila Montazersaheb, Vahid Hosseini, Saeed Rajabpour |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |