Gene delivery to breast cancer by incorporated EpCAM targeted DARPins into AAV2
Ya-feng Lv, Hao Zhang, Zhi Cui, Cui-jiao Ma, Yu-ling Li, Hua Lu, Hong-yan Wu, Jian-lin Yang, Chun-yu Cao, Wen-zheng Sun, Xiao-fei Huang · 2023
Read Gene delivery to breast cancer by incorporated EpCAM targeted DARPins into AAV2 by Ya-feng Lv, Hao Zhang, Zhi Cui, Cui-jiao Ma, Yu-ling Li, Hua Lu, Hong-yan Wu, Jian-lin Yang, Chun-yu Cao, Wen-zheng Sun, Xiao-fei Huang (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10712102.txt.
Description
Lv and co-authors build a virus that delivers genes mainly to breast cancer cells. Their carrier is a changed AAV2 virus fitted with a targeting piece called a DARPin. The DARPin, named EC1, homes in on EpCAM, a marker found on many breast cancer cells.
The team tested how specific the carrier was and how well it fought tumors. Tests ran both in cell cultures and in living models. The goal is a treatment aimed at EpCAM-positive breast cancer that spares healthy tissue. Targeted delivery could cut side effects that come with broad cancer drugs.
Catalog record
| CREATOR | Ya-feng Lv, Hao Zhang, Zhi Cui, Cui-jiao Ma, Yu-ling Li, Hua Lu, Hong-yan Wu, Jian-lin Yang, Chun-yu Cao, Wen-zheng Sun, Xiao-fei Huang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |