The preprogrammed anti-inflammatory phenotypes of CD11chigh macrophages by Streptococcus pneumoniae aminopeptidase N safeguard from allergic asthma
Shifei Yao, Danlin Weng, Yan Wang, Yanyu Zhang, Qi Huang, Kaifeng Wu, Honghui Li, Xuemei Zhang, Yibing Yin, Wenchun Xu · 2023
Read The preprogrammed anti-inflammatory phenotypes of CD11chigh macrophages by Streptococcus pneumoniae aminopeptidase N safeguard from allergic asthma by Shifei Yao, Danlin Weng, Yan Wang, Yanyu Zhang, Qi Huang, Kaifeng Wu, Honghui Li, Xuemei Zhang, Yibing Yin, Wenchun Xu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10712085.txt.
Description
Shifei Yao and co-authors studied how a bacterial protein can calm allergic asthma in this 2023 paper. The protein, called PepN, comes from the pneumonia bacterium and had already eased airway swelling in mice. Here the team traced which immune cells carry that benefit.
Mice given PepN before breathing in allergen built up a class of lung macrophages, the cells that clear debris and germs. Those cells settled into an anti-inflammatory mode, burning fuel in a calmer way. They also nudged other immune cells toward a peace-keeping type. The result was less swelling in the airways. The authors say the protein could one day help prevent allergic asthma.
Catalog record
| CREATOR | Shifei Yao, Danlin Weng, Yan Wang, Yanyu Zhang, Qi Huang, Kaifeng Wu, Honghui Li, Xuemei Zhang, Yibing Yin, Wenchun Xu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |