Targeting NR1D1 in organ injury: challenges and prospects
Zi-Yin Zhang-sun, Xue-Zeng Xu, Germaine Escames, Wang-Rui Lei, Lin Zhao, Ya-Zhe Zhou, Ye Tian, Ya-Nan Ren, Darío Acuña-Castroviejo, Yang Yang · 2023
Read Targeting NR1D1 in organ injury: challenges and prospects by Zi-Yin Zhang-sun, Xue-Zeng Xu, Germaine Escames, Wang-Rui Lei, Lin Zhao, Ya-Zhe Zhou, Ye Tian, Ya-Nan Ren, Darío Acuña-Castroviejo, Yang Yang (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10712084.txt.
Description
Zi-Yin Zhang-sun and co-authors review a clock protein as a drug target for organ injury. Their 2023 review centers on NR1D1, a heme-binding part of the body clock that mutes many clock genes. Past that role, it steers genes tied to self-eating of cells, immunity, swelling, metabolism, and aging across many organs.
Fresh finds on molecules that bind the protein mark the review's core. The protein looks like a strong target for many ills, and its levels may serve as warning marks for injury-linked disease. Human trials of its binders still lie ahead. The authors map both promise and gaps for readers in drug research.
Catalog record
| CREATOR | Zi-Yin Zhang-sun, Xue-Zeng Xu, Germaine Escames, Wang-Rui Lei, Lin Zhao, Ya-Zhe Zhou, Ye Tian, Ya-Nan Ren, Darío Acuña-Castroviejo, Yang Yang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |