Down-regulated TAB1 suppresses the replication of Coxsackievirus B5 via activating the NF-κB pathways through interaction with viral 3D polymerase
Jiayu Zhang, Peiying Teng, Bo Sun, Jihong Zhang, Xiaoshuang Zhou, Wei Chen · 2023
Read Down-regulated TAB1 suppresses the replication of Coxsackievirus B5 via activating the NF-κB pathways through interaction with viral 3D polymerase by Jiayu Zhang, Peiying Teng, Bo Sun, Jihong Zhang, Xiaoshuang Zhou, Wei Chen (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10712077.txt.
Description
Jiayu Zhang and co-authors show how a host protein fights a virus that causes hand, foot, and mouth disease, in a study from 2023. The virus, coxsackievirus B5, can also harm the brain in small children. Its copy enzyme, called 3D, is the gear the virus uses to clone its genes.
The team fished for host proteins that grip that gear and found 116 that shift with it. One, named TAB1, stuck to the gear and cut virus growth. TAB1 woke a defence path that frees alarm signals, which slowed the virus. In turn, the gear dragged TAB1 to the cell core and had it trashed, a push-back by the virus. A short span of TAB1 did most of the work. The clash maps a fresh flank for drug hunts.
Catalog record
| CREATOR | Jiayu Zhang, Peiying Teng, Bo Sun, Jihong Zhang, Xiaoshuang Zhou, Wei Chen |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |