Small-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer
Nikki L. Burdett, Madelynne O. Willis, Ahwan Pandey, Sian Fereday, D. Bowtell, D. Bowtell, G. Chenevix-Trench, A. Green, P. Webb, A. DeFazio, D. Gertig, N. Traficante, S. Fereday, S. Moore, J. Hung, K. Harrap, T. Sadkowsky, N. Pandeya, M. Malt, A. Mellon, R. Robertson, T. Vanden Bergh, M. Jones, P. · 2023
Read Small-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer by Nikki L. Burdett, Madelynne O. Willis, Ahwan Pandey, Sian Fereday, D. Bowtell, D. Bowtell, G. Chenevix-Trench, A. Green, P. Webb, A. DeFazio, D. Gertig, N. Traficante, S. Fereday, S. Moore, J. Hung, K. Harrap, T. Sadkowsky, N. Pandeya, M. Malt, A. Mellon, R. Robertson, T. Vanden Bergh, M. Jones, P. (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10711013.txt.
Description
Nikki Burdett and co-authors ask how ovarian cancers learn to resist a class of drugs that first worked well against them, in a 2023 paper. The drugs, PARP inhibitors, help patients whose tumors cannot repair DNA damage properly, a trait common in high-grade serous ovarian cancer. Resistance, though, is frequent. The team sequenced tumor samples from 26 women taken after PARP treatment, most of whose cancers carried BRCA1 or BRCA2 faults.
They scanned 63 genes tied to DNA repair and known resistance routes. Only three women carried a clear small-scale mutation explaining resistance, in the form of reversion changes that restored the broken gene. Six more carried possible mechanisms. The authors conclude that small mutations explain resistance in only a minority of cases. They urge researchers to look instead at larger DNA changes, gene activity shifts, chemical tags on DNA, and the tumor's surroundings.
Catalog record
| CREATOR | Nikki L. Burdett, Madelynne O. Willis, Ahwan Pandey, Sian Fereday, D. Bowtell, D. Bowtell, G. Chenevix-Trench, A. Green, P. Webb, A. DeFazio, D. Gertig, N. Traficante, S. Fereday, S. Moore, J. Hung, K. Harrap, T. Sadkowsky, N. Pandeya, M. Malt, A. Mellon, R. Robertson, T. Vanden Bergh, M. Jones, P. |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |