10007-ACT-2 FIRST IN HUMAN STUDY OF DSP-0390, AN ORAL EMOPAMIL BINDING PROTEIN (EBP) INHIBITOR, IN RECURRENT HIGH-GRADE GLIOMA (HGG): PRELIMINARY RESULTS
Yoshiki Arakawa, Samuel A Goldlust, Howard Colman, David A Reardon, Mary R Welch, Shigeru Yamaguchi, Nicholas A Butowski, Jian Li, Shuichi Iino, Gregory Song, Aimee Jackman, Yuran Xie, Marie-Claire Wagle, Claudia Lebedinsky, Yoshitaka Narita · 2023
Read 10007-ACT-2 FIRST IN HUMAN STUDY OF DSP-0390, AN ORAL EMOPAMIL BINDING PROTEIN (EBP) INHIBITOR, IN RECURRENT HIGH-GRADE GLIOMA (HGG): PRELIMINARY RESULTS by Yoshiki Arakawa, Samuel A Goldlust, Howard Colman, David A Reardon, Mary R Welch, Shigeru Yamaguchi, Nicholas A Butowski, Jian Li, Shuichi Iino, Gregory Song, Aimee Jackman, Yuran Xie, Marie-Claire Wagle, Claudia Lebedinsky, Yoshitaka Narita (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10710592.txt.
Description
Yoshiki Arakawa and co-authors report early human results for an oral drug that blocks cholesterol making in recurrent high-grade glioma, in a 2023 study. Brain cholesterol is made locally, since blood cannot supply it. Tumours that overproduce cholesterol genes fare worse, which hints they may be sensitive to a block.
Twenty-four patients joined the dose-rising trial across six dose levels, most with the most aggressive tumour type. No dose-limiting harms appeared. Mild nausea and a liver enzyme rise were the most common side effects, with one severe case of dry skin. Two patients with a gene-marked tumour type shrank and stayed on the drug for nine months or more. Dose-linked changes in body markers supported the drug's action.
Catalog record
| CREATOR | Yoshiki Arakawa, Samuel A Goldlust, Howard Colman, David A Reardon, Mary R Welch, Shigeru Yamaguchi, Nicholas A Butowski, Jian Li, Shuichi Iino, Gregory Song, Aimee Jackman, Yuran Xie, Marie-Claire Wagle, Claudia Lebedinsky, Yoshitaka Narita |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |