Total wash elimination for solid phase peptide synthesis
Jonathan M Collins, Sandeep K Singh, Travis A White, Drew J Cesta, Colin L Simpson, Levi J Tubb, Christopher L Houser · 2023
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Description
Jonathan Collins and co-authors remove every wash step from solid phase peptide making, in work from 2023. Washing dominates the solvent waste of peptide synthesis. Cutting it would slash both cost and environmental load.
The trick is evaporating the volatile base used in each cycle at high temperature. A directed gas flow over the vessel stops vapor from condensing back. Trials ran at research and production scales with no quality loss. Hard sequences up to eighty-nine building blocks long came out clean. Waste fell by up to ninety-five percent overall. Base use dropped to a small fraction of standard practice. Peptide drugs could get cheaper to make.
Catalog record
| CREATOR | Jonathan M Collins, Sandeep K Singh, Travis A White, Drew J Cesta, Colin L Simpson, Levi J Tubb, Christopher L Houser |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |