Amplified fluorogenic immunoassay for early diagnosis and monitoring of Alzheimer’s disease from tear fluid
Sojeong Lee, Eunjung Kim, Chae-Eun Moon, Chaewon Park, Jong-Woo Lim, Minseok Baek, Moo-Kwang Shin, Jisun Ki, Hanna Cho, Yong Woo Ji, Seungjoo Haam · 2023
Read Amplified fluorogenic immunoassay for early diagnosis and monitoring of Alzheimer’s disease from tear fluid by Sojeong Lee, Eunjung Kim, Chae-Eun Moon, Chaewon Park, Jong-Woo Lim, Minseok Baek, Moo-Kwang Shin, Jisun Ki, Hanna Cho, Yong Woo Ji, Seungjoo Haam (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10710446.txt.
Description
Catching Alzheimer's disease at its first stirrings usually means spinal taps or costly scans. Sojeong Lee and co-authors built a tear test instead in 2023. From a small discovery group they picked out a protein, CAP1, that marks the disease in tears, then built a nanoparticle assay that makes the protein's signal glow far brighter.
The test sensed the marker at vanishing levels and read it across a wide range with strong reliability. In a check group of thirty-nine people it separated patients from healthy controls with ninety percent sensitivity and perfect specificity, in under an hour. The authors pitch tear testing for screening, monitoring, and faster trials.
Catalog record
| CREATOR | Sojeong Lee, Eunjung Kim, Chae-Eun Moon, Chaewon Park, Jong-Woo Lim, Minseok Baek, Moo-Kwang Shin, Jisun Ki, Hanna Cho, Yong Woo Ji, Seungjoo Haam |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |