Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity
Jinjie Duan, Wenhui Dong, Guangyan Wang, Wenjing Xiu, Guangyin Pu, Jingwen Xu, Chenji Ye, Xu Zhang, Yi Zhu, Chunjiong Wang · 2023
Read Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity by Jinjie Duan, Wenhui Dong, Guangyan Wang, Wenjing Xiu, Guangyin Pu, Jingwen Xu, Chenji Ye, Xu Zhang, Yi Zhu, Chunjiong Wang (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10710422.txt.
Description
Jinjie Duan and co-authors wrote a mouse study from 2023 on a fat-derived signal that drives fatty liver in aging. Old liver cells, the team shows, push fat into the tissue around them. Two related lipids climb in middle-aged and old livers and in fluid from aged cells in dishes. An enzyme that makes them also rises with age. Adding the pair to young systems switched on a fat-building program and produced fatty liver.
One of the pair, 13-HODE, works by gripping catalase, a guard enzyme that clears peroxide, and switching it off. With the guard down, the fat program runs. Restoring catalase blocked the lipid's effect and shielded mice from age-related fatty liver. The authors frame the lipid as a messenger of cell aging and a target: protect the guard enzyme, and the liver stays leaner.
Catalog record
| CREATOR | Jinjie Duan, Wenhui Dong, Guangyan Wang, Wenjing Xiu, Guangyin Pu, Jingwen Xu, Chenji Ye, Xu Zhang, Yi Zhu, Chunjiong Wang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |