Analysis and Verification of Glycosylation Characteristics of Septic Acute Kidney Injury
Si Chen, Hua Gan · 2023
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Description
When sepsis injures the kidneys, the sugar coatings on proteins, called glycosylation, may be part of the story. Si Chen and Hua Gan investigate that link in a 2023 data study. They mined public gene datasets for glycosylation-related genes whose activity shifts in septic kidney injury.
Forty-five such genes emerged, clustered around glycoprotein handling and immune inflammation. Three machine learning methods then voted on the most diagnostic genes, yielding seven hub genes. Those genes tracked with immune cell patterns and with signaling and metabolism pathways. The team checked the hubs in a mouse model of sepsis-driven kidney injury, where their expression matched the data predictions. Predicted regulators and possible drug compounds for the hubs are also listed, offering leads for diagnosis and treatment research.
Catalog record
| CREATOR | Si Chen, Hua Gan |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |