Identification and Validation of Key miRNAs for Colon Cancer Based on miRNA-Gene Integration Analysis
Yi Ji, Jialin Gu, Hongqun Zhang, Houxi Xu · 2023
Read Identification and Validation of Key miRNAs for Colon Cancer Based on miRNA-Gene Integration Analysis by Yi Ji, Jialin Gu, Hongqun Zhang, Houxi Xu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10710248.txt.
Description
Yi Ji, Jialin Gu, Hongqun Zhang, and Houxi Xu present a 2023 study hunting for marker molecules in colon cancer. MicroRNAs are tiny molecules that tune gene activity, and their patterns shift in cancer. Finding the key ones could aid early diagnosis and treatment.
The team mined two public gene datasets and found fourteen microRNAs changed in both. Software predicted the genes those molecules target, and a network map singled out three key microRNAs. Lab tests on patient samples confirmed the pattern. A large cancer database gave the same answer from independent data. The authors also probed links between the three markers and immune cells inside tumors, plus markers used to guide immune therapy.
Catalog record
| CREATOR | Yi Ji, Jialin Gu, Hongqun Zhang, Houxi Xu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |