The Molecular Mechanism of Renal Tubulointerstitial Inflammation Promoting Diabetic Nephropathy
Rui Xue, Haiting Xiao, Vinod Kumar, Xiqian Lan, Ashwani Malhotra, Pravin C Singhal, Jianning Chen · 2023
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Description
Rui Xue and co-authors published a 2023 review on how inflammation inside the kidney drives diabetic kidney disease. The disease is a common complication of diabetes and a leading path to kidney failure. Older theories blamed damage to the kidney's filtering units. Newer findings show the tubules, the small tubes that process urine, are hurt early, sometimes even before the filters.
The review focuses on the tissue between the tubules, where immune cells gather and switch on. Cells there release many signals that stir up inflammation when blood sugar runs high. That inflammation then deepens the kidney damage. The authors lay out the molecular steps of this process. Understanding them could reveal new targets for diagnosis and treatment. The paper argues that calming tubule-area inflammation may expand the options for protecting diabetic kidneys.
Catalog record
| CREATOR | Rui Xue, Haiting Xiao, Vinod Kumar, Xiqian Lan, Ashwani Malhotra, Pravin C Singhal, Jianning Chen |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |