DNA methylation modulated genetic variant effect on gene transcriptional regulation
Yong Zeng, Rahi Jain, Magnus Lam, Musaddeque Ahmed, Haiyang Guo, Wenjie Xu, Yuan Zhong, Gong-Hong Wei, Wei Xu, Housheng Hansen He · 2023
Read DNA methylation modulated genetic variant effect on gene transcriptional regulation by Yong Zeng, Rahi Jain, Magnus Lam, Musaddeque Ahmed, Haiyang Guo, Wenjie Xu, Yuan Zhong, Gong-Hong Wei, Wei Xu, Housheng Hansen He (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709945.txt.
Description
Yong Zeng and co-authors present a new way to find genes whose activity is steered jointly by a DNA variant and a chemical tag on the DNA, in a 2023 paper. Standard studies link variants to gene activity but ignore methylation, the tag in question. The team had earlier verified one case where the tag changed a variant's effect, and now they test how common the pattern is.
Their method, called memo-eQTL mapping, was applied to 128 healthy prostate samples. It surfaced 1,063 variant-gene pairs governed this way, most of them invisible to standard mapping. The tag can strengthen the variant's grip on the gene or shield the gene from it, by reshaping how the DNA folds in three dimensions around a key structural protein. The authors argue this hidden layer points to new causal genes behind traits and diseases tied to DNA variants.
Catalog record
| CREATOR | Yong Zeng, Rahi Jain, Magnus Lam, Musaddeque Ahmed, Haiyang Guo, Wenjie Xu, Yuan Zhong, Gong-Hong Wei, Wei Xu, Housheng Hansen He |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |