CD147 promotes breast cancer migration and invasion by inducing epithelial-mesenchymal transition via the MAPK/ERK signaling pathway
Fang Li, Jing Wang, Yu-qiong Yan, Chong-zhi Bai, Ji-qiang Guo · 2023
Read CD147 promotes breast cancer migration and invasion by inducing epithelial-mesenchymal transition via the MAPK/ERK signaling pathway by Fang Li, Jing Wang, Yu-qiong Yan, Chong-zhi Bai, Ji-qiang Guo (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709944.txt.
Description
Fang Li and co-authors trace how a surface protein helps breast cancer spread in a 2023 study. CD147 sits on cell membranes and had been linked to several cancer behaviors, but its role in breast cancer was murky. Migration and invasion, the moves that make a tumor lethal, were the focus here.
Comparing breast cancer cell lines, the team showed that CD147 drives cells to change shape and character, a shift called epithelial-mesenchymal transition. It acts through the MAPK/ERK signaling pathway, a growth circuit many drugs already target. Blocking the protein or its pathway could slow metastasis, the stage that kills most patients. The mechanistic detail tells drug hunters exactly where to aim.
Catalog record
| CREATOR | Fang Li, Jing Wang, Yu-qiong Yan, Chong-zhi Bai, Ji-qiang Guo |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |