Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation
Ye Yang, Chun Zhao, Beili Chen, Xiaoning Yu, Yuxi Zhou, Danyu Ni, Xiaolan Zhang, Junqiang Zhang, Xiufeng Ling, Zhiguo Zhang, Ran Huo · 2023
Read Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation by Ye Yang, Chun Zhao, Beili Chen, Xiaoning Yu, Yuxi Zhou, Danyu Ni, Xiaolan Zhang, Junqiang Zhang, Xiufeng Ling, Zhiguo Zhang, Ran Huo (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709936.txt.
Description
Ye Yang and co-authors study a small peptide in the fluid around human eggs that helps those eggs mature, in a 2023 paper. Lab maturation of eggs is a tool in fertility care, but it works less well than hoped. Since eggs grow bathed in follicular fluid, the team compared the fluid's peptide mix between ripe and unripe follicles to find what helps.
One peptide stood out: C3a-peptide, a fragment snipped from a complement protein of the immune system. In cultured human and mouse eggs, it pushed more eggs to reach the mature stage. It did so by gathering the cell's actin skeleton and helping the chromosome spindle move into place. It did not raise the rate of chromosome number errors, a key safety point. The authors propose the peptide as an additive to improve lab egg maturation.
Catalog record
| CREATOR | Ye Yang, Chun Zhao, Beili Chen, Xiaoning Yu, Yuxi Zhou, Danyu Ni, Xiaolan Zhang, Junqiang Zhang, Xiufeng Ling, Zhiguo Zhang, Ran Huo |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |