Characterization of novel CD19-specific VHHs isolated from a camelid immune library by phage display
Mahmoud Ganji, Pooria Safarzadeh Kozani, Fatemeh Rahbarizadeh · 2023
Read Characterization of novel CD19-specific VHHs isolated from a camelid immune library by phage display by Mahmoud Ganji, Pooria Safarzadeh Kozani, Fatemeh Rahbarizadeh (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709854.txt.
Description
Tiny camel-style antibodies can home in on a blood cancer mark. Mahmoud Ganji, Pooria Safarzadeh Kozani, and Fatemeh Rahbarizadeh fished two such bits from a camelid library, in work from twenty twenty-three. The mark, called CD19, is a prime target on B-cell cancers. The bits are prized for their toughness and small size.
A phage display hunt over five rounds pulled out two lead bits. Both bound the mark with strong grip and clean aim in lab tests. They also stuck to cancer cell lines that wear the mark. Computer checks guessed which mark spots the bits grab. The pair now stand as candidates for tests and care tools aimed at B-cell tumors.
Catalog record
| CREATOR | Mahmoud Ganji, Pooria Safarzadeh Kozani, Fatemeh Rahbarizadeh |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |