Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase
Helene Jahn, Ladislav Bartoš, Grace I. Dearden, Jeremy S. Dittman, Joost C. M. Holthuis, Robert Vácha, Anant K. Menon · 2023
Read Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase by Helene Jahn, Ladislav Bartoš, Grace I. Dearden, Jeremy S. Dittman, Joost C. M. Holthuis, Robert Vácha, Anant K. Menon (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709637.txt.
Description
Helene Jahn and co-authors find that a well known channel protein in the outer wall of mitochondria also ferries fats into the cell's power plants. Mitochondria need fats from a sister structure, but how fats cross their outer wall was unclear. Their 2023 study names the channel, VDAC, as the ferry.
In lab made membranes, pairs of two human VDAC forms flipped fats across the layer fast, by a route apart from their channel job. Simulations show the flip happens at the pair seam, where polar parts thin the layer and draw in water. Yeast missing VDAC kin took in fats about ten times slower. The protein thus moonlights as a fat scramblase.
Catalog record
| CREATOR | Helene Jahn, Ladislav Bartoš, Grace I. Dearden, Jeremy S. Dittman, Joost C. M. Holthuis, Robert Vácha, Anant K. Menon |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 95 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |