Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging
Raquel Fernando, Anastasia V Shindyapina, Mario Ost, Didac Santesmasses, Yan Hu, Alexander Tyshkovskiy, Sun Hee Yim, Jürgen Weiss, Vadim N Gladyshev, Tilman Grune, José Pedro Castro · 2023
Read Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging by Raquel Fernando, Anastasia V Shindyapina, Mario Ost, Didac Santesmasses, Yan Hu, Alexander Tyshkovskiy, Sun Hee Yim, Jürgen Weiss, Vadim N Gladyshev, Tilman Grune, José Pedro Castro (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709625.txt.
Description
Raquel Fernando and co-authors trace fast muscle loss in aging mice to a winding-down of the cell's power plants. Their 2023 study profiles genes and small molecules in a fast-twitch leg muscle of young and old mice. Fast fibers shrink most with age, but the drivers were murky.
The biggest age shifts clustered on mitochondria, the power plants, with their processes turned down and their shapes altered. Human muscle data from a public atlas echoed the mouse pattern. Tellingly, gene marks of known life-extending treatments pointed the opposite way. The authors argue the power dip is not a bystander but a cause of decline. They pitch the signature as a screen for anti-aging leads.
Catalog record
| CREATOR | Raquel Fernando, Anastasia V Shindyapina, Mario Ost, Didac Santesmasses, Yan Hu, Alexander Tyshkovskiy, Sun Hee Yim, Jürgen Weiss, Vadim N Gladyshev, Tilman Grune, José Pedro Castro |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |