Longitudinal changes and variation in human DNA methylation analysed with the Illumina MethylationEPIC BeadChip assay and their implications on forensic age prediction
Mie Rath Refn, Mikkel Meyer Andersen, Marie-Louise Kampmann, Jacob Tfelt-Hansen, Erik Sørensen, Margit Hørup Larsen, Niels Morling, Claus Børsting, Vania Pereira · 2023
Read Longitudinal changes and variation in human DNA methylation analysed with the Illumina MethylationEPIC BeadChip assay and their implications on forensic age prediction by Mie Rath Refn, Mikkel Meyer Andersen, Marie-Louise Kampmann, Jacob Tfelt-Hansen, Erik Sørensen, Margit Hørup Larsen, Niels Morling, Claus Børsting, Vania Pereira (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709620.txt.
Description
Mie Rath Refn and co-authors report a 2023 study of DNA methylation change over 15 years. Methylation is a chemical tag on DNA that helps steer gene activity and shifts with age. Forensic teams use set tag sites to guess age, so how steady those sites are matters.
The team read genome wide tags in 64 people at two points 15 years apart with a large chip assay. A mixed model found 2,821 tag sites tied to age, with a median drift of 0.18 percent per year. Baseline levels varied a lot between people of like age, and the drift path was not uniform. Of 23 sites used in forensic age models, only one site shifted in the same path for every person.
Catalog record
| CREATOR | Mie Rath Refn, Mikkel Meyer Andersen, Marie-Louise Kampmann, Jacob Tfelt-Hansen, Erik Sørensen, Margit Hørup Larsen, Niels Morling, Claus Børsting, Vania Pereira |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |