Secreted miR-210-3p, miR-183-5p and miR-96-5p reduce sensitivity to docetaxel in prostate cancer cells
Maristella Canovai, Monica Evangelista, Alberto Mercatanti, Romina D’Aurizio, Letizia Pitto, Francesca Marrocolo, Valentina Casieri, Marco Pellegrini, Vincenzo Lionetti, Sergio Bracarda, Milena Rizzo · 2023
Read Secreted miR-210-3p, miR-183-5p and miR-96-5p reduce sensitivity to docetaxel in prostate cancer cells by Maristella Canovai, Monica Evangelista, Alberto Mercatanti, Romina D’Aurizio, Letizia Pitto, Francesca Marrocolo, Valentina Casieri, Marco Pellegrini, Vincenzo Lionetti, Sergio Bracarda, Milena Rizzo (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709610.txt.
Description
Maristella Canovai and ten colleagues showed that resistant prostate cancer cells can export their drug resistance to neighbors. Docetaxel failure is a main reason metastatic prostate cancer treatment collapses. The team found that resistant cell clones release three specific microRNAs into their surroundings. When other cancer cells take up these molecules, the chemotherapy works less well on them too. The twenty twenty-three study traced this sharing mechanism in cell experiments.
Computer analysis and lab tests identified genes the microRNAs suppress, including FOXO1 and PDCD4. Two further genes, PPP2CB and INSIG1, carried much of the resistance effect. Tiny vesicles called exosomes ferried the microRNAs between cells. Blocking this traffic could be a future strategy for keeping docetaxel effective longer in advanced prostate cancer.
Catalog record
| CREATOR | Maristella Canovai, Monica Evangelista, Alberto Mercatanti, Romina D’Aurizio, Letizia Pitto, Francesca Marrocolo, Valentina Casieri, Marco Pellegrini, Vincenzo Lionetti, Sergio Bracarda, Milena Rizzo |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |