Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses
Chuanyuan Wei, Wei Sun, Kangjie Shen, Jingqin Zhong, Wanlin Liu, Zixu Gao, Yu Xu, Lu Wang, Tu Hu, Ming Ren, Yinlam Li, Yu Zhu, Shaoluan Zheng, Ming Zhu, Rongkui Luo, Yanwen Yang, Yingyong Hou, Fazhi Qi, Yuhong Zhou, Yong Chen, Jianying Gu · 2023
Read Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses by Chuanyuan Wei, Wei Sun, Kangjie Shen, Jingqin Zhong, Wanlin Liu, Zixu Gao, Yu Xu, Lu Wang, Tu Hu, Ming Ren, Yinlam Li, Yu Zhu, Shaoluan Zheng, Ming Zhu, Rongkui Luo, Yanwen Yang, Yingyong Hou, Fazhi Qi, Yuhong Zhou, Yong Chen, Jianying Gu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709603.txt.
Description
Chuanyuan Wei and co-authors present a 2023 study of how acral melanoma, a rare skin cancer of the hands and feet, spreads early. This form reaches the lymph nodes often, and that spread drives treatment choices. The team combined single-cell gene reading with maps that keep each cell's place in the tissue.
Their data show wide variety both between tumours and inside one tumour. The tissue around the cancer strongly suppresses immune attack, and the web of signals between cells is complex. By tracing how the tumour's cell mix changes as it starts to spread, the study names early steps that future treatments might block.
Catalog record
| CREATOR | Chuanyuan Wei, Wei Sun, Kangjie Shen, Jingqin Zhong, Wanlin Liu, Zixu Gao, Yu Xu, Lu Wang, Tu Hu, Ming Ren, Yinlam Li, Yu Zhu, Shaoluan Zheng, Ming Zhu, Rongkui Luo, Yanwen Yang, Yingyong Hou, Fazhi Qi, Yuhong Zhou, Yong Chen, Jianying Gu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 87 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |