FilGAP regulates tumor growth in Glioma through the regulation of mTORC1 and mTORC2
Koji Tsutsumi, Ayumi Nohara, Taiki Tanaka, Moe Murano, Yurina Miyagaki, Yasutaka Ohta · 2023
Read FilGAP regulates tumor growth in Glioma through the regulation of mTORC1 and mTORC2 by Koji Tsutsumi, Ayumi Nohara, Taiki Tanaka, Moe Murano, Yurina Miyagaki, Yasutaka Ohta (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709582.txt.
Description
Koji Tsutsumi and co-authors studied how the protein FilGAP affects the growth signaling of glioma, an aggressive brain tumor, in a 2023 paper. A growth pathway built around the kinase mTOR runs hot in many tumors, glioma included. FilGAP normally brakes a related switch protein, and the team found it also binds both mTOR complexes.
Removing FilGAP from one glioma cell line lowered the pathway's activity markers, while adding it raised them. A second, more active line needed an extra drug before the same effect showed. Knocking FilGAP down shrank tumor-like spheres in both lines. The authors suggest FilGAP helps drive glioma growth through this pathway.
Catalog record
| CREATOR | Koji Tsutsumi, Ayumi Nohara, Taiki Tanaka, Moe Murano, Yurina Miyagaki, Yasutaka Ohta |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |