Chiral metal-organic frameworks incorporating nanozymes as neuroinflammation inhibitors for managing Parkinson’s disease
Wei Jiang, Qing Li, Ruofei Zhang, Jianru Li, Qianyu Lin, Jingyun Li, Xinyao Zhou, Xiyun Yan, Kelong Fan · 2023
Read Chiral metal-organic frameworks incorporating nanozymes as neuroinflammation inhibitors for managing Parkinson’s disease by Wei Jiang, Qing Li, Ruofei Zhang, Jianru Li, Qianyu Lin, Jingyun Li, Xinyao Zhou, Xiyun Yan, Kelong Fan (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709450.txt.
Description
Wei Jiang and co-authors report a new kind of tiny drug carrier aimed at brain swelling in Parkinson's disease, in a 2023 paper. The team built cage-like frames that hold even smaller platinum particles, which act like enzymes that mop up harmful oxygen compounds. They made two mirror-image forms of the frame, a left-handed one and a right-handed one, to see which works better.
In tests with male mice that model the disease, the right-handed form stayed in the blood longer and crossed into the brain by more routes. It eased movement problems and tissue damage more than its twin. Lab checks suggest the carrier also stops two forms of cell death in harmed nerve cells. The work points to shape itself as a design tool for brain drugs.
Catalog record
| CREATOR | Wei Jiang, Qing Li, Ruofei Zhang, Jianru Li, Qianyu Lin, Jingyun Li, Xinyao Zhou, Xiyun Yan, Kelong Fan |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |