Diversity of symptom phenotypes in SARS-CoV-2 community infections observed in multiple large datasets
Martyn Fyles, Karina-Doris Vihta, Carole H Sudre, Harry Long, Rajenki Das, Caroline Jay, Tom Wingfield, Fergus Cumming, William Green, Pantelis Hadjipantelis, Joni Kirk, Claire J Steves, Sebastien Ourselin, Graham F Medley, Elizabeth Fearon, Thomas House · 2023
Read Diversity of symptom phenotypes in SARS-CoV-2 community infections observed in multiple large datasets by Martyn Fyles, Karina-Doris Vihta, Carole H Sudre, Harry Long, Rajenki Das, Caroline Jay, Tom Wingfield, Fergus Cumming, William Green, Pantelis Hadjipantelis, Joni Kirk, Claire J Steves, Sebastien Ourselin, Graham F Medley, Elizabeth Fearon, Thomas House (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709437.txt.
Description
Fyles and a large team study symptom patterns in community COVID-19 cases in twenty twenty-three. Symptoms varied widely from the first months of the pandemic. That variety may reflect unlike paths from infection to illness. For public health, symptoms also guided who got tested and who isolated.
The team combined four large United Kingdom data sets. They used machine learning and statistical clustering to find symptom phenotypes. Cases were all community infections with a positive PCR test. Beyond a split by total symptom count, symptoms grouped into gut, respiratory, and other types. Patterns of co-occurring symptoms also differed at the youngest and oldest ages. The authors say the method avoids biases from study design. It could extend to other diseases and syndromes.
Catalog record
| CREATOR | Martyn Fyles, Karina-Doris Vihta, Carole H Sudre, Harry Long, Rajenki Das, Caroline Jay, Tom Wingfield, Fergus Cumming, William Green, Pantelis Hadjipantelis, Joni Kirk, Claire J Steves, Sebastien Ourselin, Graham F Medley, Elizabeth Fearon, Thomas House |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |