Local production of reactive oxygen species drives vincristine-induced axon degeneration
Jorge Gomez-Deza, Anastasia L Slavutsky, Matthew Nebiyou, Claire E Le Pichon · 2023
Read Local production of reactive oxygen species drives vincristine-induced axon degeneration by Jorge Gomez-Deza, Anastasia L Slavutsky, Matthew Nebiyou, Claire E Le Pichon (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709426.txt.
Description
Jorge Gomez-Deza and co-authors published a study in 2023 on how a common chemotherapy drug damages nerve fibers. Side effects like pain and thinking trouble can force dose cuts that hurt cancer outcomes. The team used human neurons grown from stem cells to trace the harm from the drug vincristine. They looked for the chain of events inside the fiber.
The drug raised levels of mitochondrial proteins in the fiber that make reactive oxygen species. That rise drove mitochondrial failure, more of these reactive molecules, and fiber breakdown through a known pathway. Two protective compounds and a blocker of mitochondrial splitting reduced the harm in the tests. The authors name this as a fresh route to guard nerves during treatment.
Catalog record
| CREATOR | Jorge Gomez-Deza, Anastasia L Slavutsky, Matthew Nebiyou, Claire E Le Pichon |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |