A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging
Carolin Thomas, Reto Erni, Jia Yee Wu, Fabian Fischer, Greta Lamers, Giovanna Grigolon, Sarah J. Mitchell, Kim Zarse, Erick M. Carreira, Michael Ristow · 2023
Read A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging by Carolin Thomas, Reto Erni, Jia Yee Wu, Fabian Fischer, Greta Lamers, Giovanna Grigolon, Sarah J. Mitchell, Kim Zarse, Erick M. Carreira, Michael Ristow (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709416.txt.
Description
Carrots hold a little-known compound that may slow aging, at least in worms and mice. Carolin Thomas and co-authors isolated and tested that compound in this 2023 study. It belongs to a family called polyacetylenes. The team named it isofalcarintriol and pinned down its exact three-dimensional shape.
A step-by-step lab recipe was built to make every mirror form of the compound. In roundworms it extended life and improved movement and stress resistance. In mammal cells and mice it changed breathing at the power-plant level. The compound binds a part of the cell's main energy machine and spurs growth of new power plants. Cancer cells grew more slowly under it. A carrot chemical is now a lead for healthy-aging research.
Catalog record
| CREATOR | Carolin Thomas, Reto Erni, Jia Yee Wu, Fabian Fischer, Greta Lamers, Giovanna Grigolon, Sarah J. Mitchell, Kim Zarse, Erick M. Carreira, Michael Ristow |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 93 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |