Low incidence of microsatellite instability in gastric cancers and its association with the clinicopathological characteristics: a comparative study
Fateme Fooladi Talari, Ali Bozorg, Sirous Zeinali, Mohammadreza Zali, Zhale Mohsenifar, Hamid Asadzadeh Aghdaei, Kaveh Baghaei · 2023
Read Low incidence of microsatellite instability in gastric cancers and its association with the clinicopathological characteristics: a comparative study by Fateme Fooladi Talari, Ali Bozorg, Sirous Zeinali, Mohammadreza Zali, Zhale Mohsenifar, Hamid Asadzadeh Aghdaei, Kaveh Baghaei (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709324.txt.
Description
Fateme Fooladi Talari and co-authors measured this 2023 rate of a DNA-repair glitch in Iranian stomach cancers. Some tumors carry microsatellite instability, a marker that predicts a better outlook and different treatment response. World rates vary, and Middle East data were missing. The team collected 53 tumor samples from a Tehran hospital, gathered between 2015 and 2020, and tested tumor against normal tissue.
Only about 7.5 percent of samples showed the high-instability pattern, four patients in all. That small group differed significantly from the rest on some clinical traits. The authors compared age, sex, tumor type, stage, and spread against the marker's status. Their low rate suggests this favorable subgroup is uncommon in Iranian patients, which matters for planning immunotherapy trials there.
Catalog record
| CREATOR | Fateme Fooladi Talari, Ali Bozorg, Sirous Zeinali, Mohammadreza Zali, Zhale Mohsenifar, Hamid Asadzadeh Aghdaei, Kaveh Baghaei |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |