A breast cancer classification and immune landscape analysis based on cancer stem-cell-related risk panel
Haihong Hu, Mingxiang Zou, Hongjuan Hu, Zecheng Hu, Lingxiang Jiang, David Escobar, Hongxia Zhu, Wendi Zhan, Ting Yan, Taolan Zhang · 2023
Read A breast cancer classification and immune landscape analysis based on cancer stem-cell-related risk panel by Haihong Hu, Mingxiang Zou, Hongjuan Hu, Zecheng Hu, Lingxiang Jiang, David Escobar, Hongxia Zhu, Wendi Zhan, Ting Yan, Taolan Zhang (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709318.txt.
Description
Haihong Hu and co-authors sort breast cancers by genes tied to cancer stem cells, in a 2023 study. Stem-like cells in tumors can drive growth and resist care. The team used genes linked to patient outcomes to group tumors into types. They then built a risk score from those genes.
Several methods were layered: grouping, network analysis, and machine learning with two forms of regression. The score aims to predict outlook and chances of benefit from immune therapy. The authors also mapped immune cells in and around the tumors. One small cell group was singled out and its place in the tumor was studied. The work links stem-cell traits to both prognosis and immune layout.
Catalog record
| CREATOR | Haihong Hu, Mingxiang Zou, Hongjuan Hu, Zecheng Hu, Lingxiang Jiang, David Escobar, Hongxia Zhu, Wendi Zhan, Ting Yan, Taolan Zhang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |