Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Jenna M Giafaglione, Preston D Crowell, Amelie M L Delcourt, Takao Hashimoto, Sung Min Ha, Aishwarya Atmakuri, Nicholas M Nunley, Rachel M A Dang, Mao Tian, Johnny A Diaz, Elisavet Tika, Marie C Payne, Deborah L Burkhart, Dapei Li, Nora M Navone, Eva Corey, Peter S Nelson, Neil Y C Lin, Cedric Blanp · 2023
Read Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment by Jenna M Giafaglione, Preston D Crowell, Amelie M L Delcourt, Takao Hashimoto, Sung Min Ha, Aishwarya Atmakuri, Nicholas M Nunley, Rachel M A Dang, Mao Tian, Johnny A Diaz, Elisavet Tika, Marie C Payne, Deborah L Burkhart, Dapei Li, Nora M Navone, Eva Corey, Peter S Nelson, Neil Y C Lin, Cedric Blanp (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10709144.txt.
Description
Jenna Giafaglione and co-authors show that how prostate cells burn fuel helps decide what type of cell they become. Their 2023 study notes that shifts between prostate cell lineages drive development, tumor growth, and resistance to hormone-blocking drugs. Gene-based control of these shifts was known, but the role of metabolism upstream was not.
The team built a way to profile chemicals in fresh prostate cells. Basal and luminal cells showed distinct fuel use, and maturing into luminal cells raised one fuel-burning path. Blocking that path, or adding lactate, reshaped gene control and changed response to hormone drugs. Metabolism and identity regulate each other. The findings may matter for men whose cancers stop responding to hormone therapy.
Catalog record
| CREATOR | Jenna M Giafaglione, Preston D Crowell, Amelie M L Delcourt, Takao Hashimoto, Sung Min Ha, Aishwarya Atmakuri, Nicholas M Nunley, Rachel M A Dang, Mao Tian, Johnny A Diaz, Elisavet Tika, Marie C Payne, Deborah L Burkhart, Dapei Li, Nora M Navone, Eva Corey, Peter S Nelson, Neil Y C Lin, Cedric Blanp |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 101 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |