Spectrophotometric Study of Charge-Transfer Complexes of Ruxolitinib with Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone: An Application to the Development of a Green and High-Throughput Microwell Method for Quantification of Ruxolitinib in Its Pharmaceutical Formulations
Khalid A Aljaber, Ibrahim A Darwish, Abdullah M Al-Hossaini, Alessandra Biancolillo, Angelo Antonio D’Archivio · 2023
Read Spectrophotometric Study of Charge-Transfer Complexes of Ruxolitinib with Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone: An Application to the Development of a Green and High-Throughput Microwell Method for Quantification of Ruxolitinib in Its Pharmaceutical Formulations by Khalid A Aljaber, Ibrahim A Darwish, Abdullah M Al-Hossaini, Alessandra Biancolillo, Angelo Antonio D’Archivio (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10708051.txt.
Description
Aljaber and co-authors study colored complexes formed by the drug ruxolitinib with two acceptor compounds. Ruxolitinib treats blood disorders and graft-versus-host disease. The drug acts as an electron donor toward chloranilic acid and DDQ. Their pairing creates charge-transfer complexes with new light absorption bands. Peaks sat at 530 and 470 nanometers for the two partners. Each complex formed in a one-to-one ratio.
The team measured the complexes' light and electronic traits in detail. Those data support a quick assay method built on microwell plates. The method aims to measure the drug in its dose forms at high volume. The authors stress the method's green, low-waste profile.
Catalog record
| CREATOR | Khalid A Aljaber, Ibrahim A Darwish, Abdullah M Al-Hossaini, Alessandra Biancolillo, Angelo Antonio D’Archivio |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |