A Ropy Exopolysaccharide-Producing Strain Bifidobacterium pseudocatenulatum Bi-OTA128 Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice
Hui Wang, Xinyuan Zhang, Xinfang Kou, Zhengyuan Zhai, Yanling Hao · 2023
Read A Ropy Exopolysaccharide-Producing Strain Bifidobacterium pseudocatenulatum Bi-OTA128 Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice by Hui Wang, Xinyuan Zhang, Xinfang Kou, Zhengyuan Zhai, Yanling Hao (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10707796.txt.
Description
Hui Wang and four co-authors wrote this 2023 study on a gut bacterium that might calm inflamed bowels. The strain makes a ropy sugar coating, and the team wondered whether that coating is the source of its benefit. They fed the bacterium to mice with chemically induced colitis, alongside a cousin strain that makes no coating.
Treated mice kept healthier gut barriers, with more mucus protein and tighter cell seals. Oxidative stress fell as protective enzymes rose, and inflammatory signals dropped while a calming one climbed. The coated strain also reshaped the gut community, boosting helpful bacteria and crowding out harmful ones, and it fed partner microbes that produce useful acids. It outperformed the uncoated strain on the microbial measures. The authors nominate it as a probiotic candidate for supporting recovery during colitis.
Catalog record
| CREATOR | Hui Wang, Xinyuan Zhang, Xinfang Kou, Zhengyuan Zhai, Yanling Hao |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |