Second Wave, Late-Stage Neuroinflammation in Cleared Brains of Aged 5xFAD Alzheimer’s Mice Detected by Macrolaser Light Sheet Microscopy Imaging
Suk Hyun Lee, Hye Joo Son, Alvaro Galli, Lilach Soreq · 2023
Read Second Wave, Late-Stage Neuroinflammation in Cleared Brains of Aged 5xFAD Alzheimer’s Mice Detected by Macrolaser Light Sheet Microscopy Imaging by Suk Hyun Lee, Hye Joo Son, Alvaro Galli, Lilach Soreq (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10707588.txt.
Description
Suk Hyun Lee and co-authors image whole cleared mouse brains to map Alzheimer's damage in three dimensions. Their 2023 study uses aged 5xFAD mice, a strain bred to develop amyloid disease. Brains were made transparent, stained for amyloid, microglia, and astrocytes, then scanned with a macrolaser light sheet microscope.
The diseased brains held far more amyloid volume than controls, with wide variation between animals. Inflammation markers also ran higher, and the team reports a late second wave of neuroinflammation in the aged diseased brains. Whole-brain maps catch patterns that thin slices miss, such as where particles cluster and how big each grows. Alzheimer's researchers get a fuller spatial record of plaques and immune cells together.
Catalog record
| CREATOR | Suk Hyun Lee, Hye Joo Son, Alvaro Galli, Lilach Soreq |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |