Ubiquitination of Major Histocompatibility Complex II Changes Its Immunological Recognition Structure
Yuko Kozono, Masahiro Kuramochi, Yuji C. Sasaki, Haruo Kozono · 2023
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Description
Yuko Kozono and co-authors show in this 2023 study that a disposal tag changes how immune display molecules talk to T cells. MHC class II molecules show protein scraps to helper T cells, and a ubiquitin tag normally sets their lifespan on the cell surface. Using dendritic cells missing the tagging enzyme, the team watched display behavior with a single-molecule X-ray method on live cells.
Tagged molecules moved faster on the surface and bound a checkpoint partner, LAG-3, more weakly when the tag was heavy. Removing the tag slowed movement. The authors suggest tagged displays linger to present antigen rather than vanish, shaping the immune reply. Drug design for immune checks may borrow the trick.
Catalog record
| CREATOR | Yuko Kozono, Masahiro Kuramochi, Yuji C. Sasaki, Haruo Kozono |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |