Brain-Specific Angiogenesis Inhibitor 3 Is Expressed in the Cochlea and Is Necessary for Hearing Function in Mice
Chika Saegusa, Wataru Kakegawa, Eriko Miura, Takahiro Aimi, Sachiyo Mogi, Tatsuhiko Harada, Taku Yamashita, Michisuke Yuzaki, Masato Fujioka, Kazuhiko Nakadate · 2023
Read Brain-Specific Angiogenesis Inhibitor 3 Is Expressed in the Cochlea and Is Necessary for Hearing Function in Mice by Chika Saegusa, Wataru Kakegawa, Eriko Miura, Takahiro Aimi, Sachiyo Mogi, Tatsuhiko Harada, Taku Yamashita, Michisuke Yuzaki, Masato Fujioka, Kazuhiko Nakadate (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10707444.txt.
Description
Saegusa and co-authors find that a receptor first named for brain blood vessels also builds a key structure of the inner ear. Sound-sensing hair cells need neighboring pillar cells, which form a tunnel that fine-tunes hearing. Their 2023 study tracks the receptor, Bai3, in mouse ears across ages.
Young mice showed the receptor in hair cells, adults in pillar cells. Mice lacking it formed pillar cells abnormally and heard worse, with thresholds lifted more at some pitches than others. Old knockout mice also lost hair cells and nerve cells at the ear's high-pitch end. The authors conclude the receptor helps build or maintain the pillar scaffold. They suggest relevance to human hearing loss.
Catalog record
| CREATOR | Chika Saegusa, Wataru Kakegawa, Eriko Miura, Takahiro Aimi, Sachiyo Mogi, Tatsuhiko Harada, Taku Yamashita, Michisuke Yuzaki, Masato Fujioka, Kazuhiko Nakadate |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |