Radiolabeling of Platelets with 99mTc-HYNIC-Duramycin for In Vivo Imaging Studies
Keresztély Merkel, Dávid Szöllősi, Ildikó Horváth, Bálint Jezsó, Zsolt Baranyai, Krisztián Szigeti, Zoltán Varga, Imre Hegedüs, Parasuraman Padmanabhan, Balázs Gulyás, Ralf Bergmann, Domokos Máthé, Ludmilla A Morozova-Roche · 2023
Read Radiolabeling of Platelets with 99mTc-HYNIC-Duramycin for In Vivo Imaging Studies by Keresztély Merkel, Dávid Szöllősi, Ildikó Horváth, Bálint Jezsó, Zsolt Baranyai, Krisztián Szigeti, Zoltán Varga, Imre Hegedüs, Parasuraman Padmanabhan, Balázs Gulyás, Ralf Bergmann, Domokos Máthé, Ludmilla A Morozova-Roche (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10707319.txt.
Description
Keresztély Merkel and co-authors label blood platelets with a radioactive tag for body imaging, in a 2023 paper. Tracking platelets inside the body would clarify their roles in health and disease. The imaging method used, SPECT, needs the tag to stay on the platelets and leave them unharmed.
Their tag pairs a common medical isotope with duramycin, a small peptide that grips cell membranes. The peptide did not meaningfully activate the platelets, a key safety check. Labeling took one step, followed by a clean-up pass. Human platelets labeled this way were injected into mice, and scans showed them gathering in spleen and liver, not lungs, with the label holding steady. The method readies platelet tracking for wider study.
Catalog record
| CREATOR | Keresztély Merkel, Dávid Szöllősi, Ildikó Horváth, Bálint Jezsó, Zsolt Baranyai, Krisztián Szigeti, Zoltán Varga, Imre Hegedüs, Parasuraman Padmanabhan, Balázs Gulyás, Ralf Bergmann, Domokos Máthé, Ludmilla A Morozova-Roche |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |