Ligand Recognition by the Macrophage Galactose-Type C-Type Lectin: Self or Non-Self?—A Way to Trick the Host’s Immune System
Justyna Szczykutowicz · 2023
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Description
Szczykutowicz reviews in 2023 how a macrophage lectin reads sugar tags on cells, and how tumors and pathogens abuse that reading. The lectin, MGL, sits on antigen presenting cells and binds sugars ending in a set residue found on some antigens. Its normal job is calming immunity to keep balance.
That calming effect is exactly what cancers and some pathogens exploit to escape immune control. The review covers immune outcomes of ligand binding, the molecular details of the contacts, and the ligands found so far. It closes with a hypothesis about maternal tolerance, asking whether the same lectin helps a mother accept sperm and the fetus.
Catalog record
| CREATOR | Justyna Szczykutowicz |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |