Enhancement of Radiation Sensitivity by Cathepsin L Suppression in Colon Carcinoma Cells
Ramadan F Abdelaziz, Ahmed M Hussein, Mohamed H Kotob, Christina Weiss, Krzysztof Chelminski, Tamara Stojanovic, Christian R Studenik, Mohammed Aufy, Nitin Telang · 2023
Read Enhancement of Radiation Sensitivity by Cathepsin L Suppression in Colon Carcinoma Cells by Ramadan F Abdelaziz, Ahmed M Hussein, Mohamed H Kotob, Christina Weiss, Krzysztof Chelminski, Tamara Stojanovic, Christian R Studenik, Mohammed Aufy, Nitin Telang (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10707098.txt.
Description
Ramadan Abdelaziz and co-authors test whether blocking an enzyme called cathepsin L makes colon cancer cells easier to kill with radiation. Their 2023 study starts from a clinical problem: tumors often resist radiotherapy, the DNA-damaging treatment that anchors much cancer care. The enzyme had been tied to that resistance.
In colon cancer cells, radiation itself raised the enzyme's level. Cells treated with a specific blocker, or edited to delete the enzyme's gene, died more readily at each radiation dose. Protein checks and death assays backed the shift. The cells seemed less able to repair radiation damage once the enzyme was gone. The authors propose the enzyme as a drug target to pair with radiotherapy. More work is needed on the mechanism and on safety in living tissue.
Catalog record
| CREATOR | Ramadan F Abdelaziz, Ahmed M Hussein, Mohamed H Kotob, Christina Weiss, Krzysztof Chelminski, Tamara Stojanovic, Christian R Studenik, Mohammed Aufy, Nitin Telang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |